How We and Our Partners Employ the Technology
Half-life extension of proteins, including antibodies and antibody fragments
Overcoming immunogenicity of foreign polypeptides
Programmed release of small molecules
Targeting of POZ-polymers to specific receptors and target tissues
Half-Life Extension of Protiens
Does POZ prolong the half-life of protiens and retain biological activity?
Effect of G-CSF, 10 kDa-N(ter), 20 kDa-N(ter) and 20 kDa-Gln G-CSFs on Neutrophil (A) and total WBC counts (B) in male Sprague-Dawley rats following IV infusion of compounds
Mero A, Fang Z, Pasut G, Veronese FM, Viegas TX, Selective conjugation of poly(2-ethyl 2-oxazoline) to granulocyte colony stimulating factor. J Control Release, (Mar 3 2012)
POZ Camouflages Immunogenicity of Foreign Proteins
Viegas, T.X., Bentley, M.B., Harris, J.M., Fang Z., Yoon, K., Dizman, B., Weimer, R., Mero, A., Pasut, G., and Veronese, F.M., Polyoxazoline: chemistry, properties and applications in drug delivery. Bioconjugate Chemistry, 22, 976-986 (2011).
Relative immunogenicity of BSA, PEG BSA, and PEOZ BSA in rabbits treated as measured by anti-BSA antibody levels.
Rotigotine Release Is Controlled By Linker Chemistry
Hydrolis of rotigotine is controlled by the nature of the ester linker attached to the polymer backbone.
SER-214 gave the longest t 1/2 and was chosen as the lead candidate for Parkinson’s Disease
SOURCE: Mov Disorder. 2013 Oct;28(12):1675-82. doi: 10.1002/mds.25625. Epub 2013 Sep 3.
Mouse Xenograft Model – KB Ca
Folate-targeted POZ-irinotecan eradicates KB tumors
- KB carcinomas are markedly resistant to irinotecan
- Two course of irinotecan alone (red) fail to suppress tumors at any size (small or large; mouse in left portion of photo)
- A single course of irinotecan, followed by a single course of SER-203 (POZ-irinotecan targeted to the high affinity folate receptor alpha) administered when the tumor is ~10x the original size (purple), results in complete eradication of tumors (mouse in right portion of photo)